Berikut daftar sementara pembalap MotoGP 2021 per 1 Oktober 2020.
- Repsol Honda: Marc Marquez, Pol Espargaro
- Monster Energy Yamaha: Maverick Vinales, Fabio Quartararo
- Ducati: Jack Miller, Francesco Bagnaia
- Suzuki Ecstar: Alex Rins, Joan Mir
- KTM Red Bull: Brad Binder, Miguel Oliveira
- Aprilia Gresini: Aleix Espargaro
- LCR Honda: Alex Marquez
- Petronas Yamaha SRT: Valentino Rossi, Franco Morbidelli
- Pramac Racing: Johann Zarco, Jorge Martin
- KTM Tech3: Danilo Petrucci, Iker Lecuona
- Esponsorama Racing: Tito Rabat, Enea Bastianini
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