Dalam balapan dalam kondisi trek kering kali ini, ada delapan pembalap yang gagal finis akibat kecelakaan.
Berikut hasil lengkap MotoGP Emilia Romagna 2021, Minggu (24/10/2021)
| POS. | PEMBALAP | TIM | WAKTU/GAP |
| 1 | Marc Marquez | Repsol Honda (RC213V) | 41m 52.83s |
| 2 | Pol Espargaro | Repsol Honda (RC213V) | +4.859s |
| 3 | Enea Bastianini | Avintia Ducati (GP19)* | +12.013s |
| 4 | Fabio Quartararo | Monster Yamaha (YZR-M1) | +12.775s |
| 5 | Johann Zarco | Pramac Ducati (GP21) | +16.458s |
| 6 | Alex Rins | Suzuki Ecstar (GSX-RR) | +17.669s |
| 7 | Aleix Espargaro | Aprilia Gresini (RS-GP) | +18.468s |
| 8 | Maverick Viñales | Aprilia Gresini (RS-GP) | +18.607s |
| 9 | Luca Marini | Sky VR46 Avintia Ducati (GP19)* | +25.417s |
| 10 | Valentino Rossi | Petronas Yamaha (YZR-M1) | +27.735s |
| 11 | Brad Binder | Red Bull KTM (RC16) | +27.879s |
| 12 | Michele Pirro | Ducati Team (GP21) | +28.137s |
| 13 | Andrea Dovizioso | Petronas Yamaha (YZR-M1) | +41.413s |
| 14 | Franco Morbidelli | Monster Yamaha (YZR-M1) | +42.830s |
| 15 | Takaaki Nakagami | LCR Honda (RC213V) | +22.462s |
| Francesco Bagnaia | Ducati Team (GP21) | DNF | |
| Miguel Oliveira | Red Bull KTM (RC16) | DNF | |
| Jorge Martin | Pramac Ducati (GP21)* | DNF | |
| Iker Lecuona | KTM Tech3 (RC16) | DNF | |
| Alex Marquez | LCR Honda (RC213V) | DNF | |
| Jack Miller | Ducati Team (GP21) | DNF | |
| Danilo Petrucci | KTM Tech3 (RC16) | DNF | |
| Joan Mir | Suzuki Ecstar (GSX-RR) | DNF |
*pembalap rookie
**DNF = gagal finis