Namun lambat laun ia berhasil merangsak naik dan menembus lima besar serta nyaris podium.
Sayangnya, ambisi Fabio mengamankan podium ketiga terenggut Enea Bastianini (Avintia Ducati) yang menikung di putaran terakhir.
Meski gagal podium, Fabio Quartararo tetap sukses mencetak sejarah.
Tak hanya menjadi pembalap Prancis pertama yang juara dunia, tetapi ia juga menjadi juara dunia dari tim Yamaha sejak 2015 yang diraih Jorge Lorenzo.
Berikut update klasemen MotoGP 2021 usai balapan MotoGP Emilia Romagna 2021.
| POS. | PEMBALAP | TIM | POIN | SELISIH. |
| 1 | Fabio Quartararo | Monster Yamaha (YZR-M1) | 267 | |
| 2 | Francesco Bagnaia | Ducati Team (GP21) | 202 | (-65) |
| 3 | Joan Mir | Suzuki Ecstar (GSX-RR) | 175 | (-92) |
| 4 | Johann Zarco | Pramac Ducati (GP21) | 152 | (-115) |
| 5 | Jack Miller | Ducati Team (GP21) | 149 | (-118) |
| 6 | Marc Marquez | Repsol Honda (RC213V) | 142 | (-125) |
| 7 | Brad Binder | Red Bull KTM (RC16) | 136 | (-131) |
| 8 | Aleix Espargaro | Aprilia Gresini (RS-GP) | 113 | (-154) |
| 9 | Maverick Viñales | Aprilia Gresini (RS-GP) | 106 | (-161) |
| 10 | Miguel Oliveira | Red Bull KTM (RC16) | 92 | (-175) |
| 11 | Alex Rins | Suzuki Ecstar (GSX-RR) | 91 | (-176) |
| 12 | Pol Espargaro | Repsol Honda (RC213V) | 90 | (-177) |
| 13 | Enea Bastianini | Avintia Ducati (GP19)* | 87 | (-180) |
| 14 | Jorge Martin | Pramac Ducati (GP21)* | 82 | (-185) |
| 15 | Takaaki Nakagami | LCR Honda (RC213V) | 71 | (-196) |
| 16 | Alex Marquez | LCR Honda (RC213V) | 54 | (-213) |
| 17 | Franco Morbidelli | Monster Yamaha (YZR-M1) | 42 | (-225) |
| 18 | Iker Lecuona | KTM Tech3 (RC16) | 38 | (-229) |
| 19 | Danilo Petrucci | KTM Tech3 (RC16) | 37 | (-230) |
| 20 | Luca Marini | Sky VR46 Avintia Ducati (GP19)* | 37 | (-230) |
| 21 | Valentino Rossi | Petronas Yamaha (YZR-M1) | 35 | (-232) |
| 22 | Stefan Bradl | HRC (RC213V) | 13 | (-254) |
| 23 | Michele Pirro | Ducati Team (GP21) | 12 | (-255) |
| 24 | Dani Pedrosa | Red Bull KTM (RC16) | 6 | (-261) |
| 25 | Andrea Dovizioso | Petronas Yamaha (YZR-M1) | 6 | (-261) |
| 26 | Lorenzo Savadori | Aprilia Gresini (RS-GP)* | 4 | (-263) |
| 27 | Tito Rabat | Pramac Ducati (GP21) | 1 | (-266 |
*pembalap rookie