Baca Juga: MotoGP Italia 2022 - Penderitaan Marc Marquez Sudah Dimulai Sejak Hari Pertama
Rider Prancis itu mengukir lap tercepat 1 menit 45, 767 detik dan melahap 18 putaran.
Posisi lima besar ditutup oleh jebolan VR46 Riders Academy, Marco Bezzecchi.
Rekan setim Marini itu total membuat 17 putaran dengan catatan lap tercepat 1 menit 45, 853 detik.
Sementara itu, juara dunia MotoGP 2021 Fabio Quartararo harus tercecer di urutan kesepuluh.
Pembalap andalan Yamaha itu hanya mampu mengukit catatan waktu terbaik 1 menit 46, 032 detik.
Hasil sama juga didapatkan Marc Marquez.
Juara dunia enam kali asal Honda itu terperosok ke urutan ke-21 dengan putaran terbaik 1 menit 46, 577 detik.
Berikut hasil FP3 MotoGP Italia 2022.
| POS | RIDER | NAT | TEAM | TIME/DIFF |
| 1 | Francesco Bagnaia | ITA | Ducati Lenovo (GP22) | 1'45.393s |
| 2 | Aleix Espargaro | SPA | Aprilia Racing (RS-GP) | +0.276s |
| 3 | Luca Marini | ITA | Mooney VR46 Ducati (GP22) | +0.369s |
| 4 | Johann Zarco | FRA | Pramac Ducati (GP22) | +0.374s |
| 5 | Marco Bezzecchi | ITA | Mooney VR46 Ducati (GP21)* | +0.460s |
| 6 | Enea Bastianini | ITA | Gresini Ducati (GP21) | +0.467s |
| 7 | Jorge Martin | SPA | Pramac Ducati (GP22) | +0.486s |
| 8 | Pol Espargaro | SPA | Repsol Honda (RC213V) | +0.487s |
| 9 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | +0.606s |
| 10 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | +0.639s |
| 11 | Maverick Vinales | SPA | Aprilia Racing (RS-GP) | +0.667s |
| 12 | Alex Rins | SPA | Suzuki Ecstar (GSX-RR) | +0.671s |
| 13 | Fabio Di Giannantonio | ITA | Gresini Ducati (GP21)* | +0.723s |
| 14 | Miguel Oliveira | POR | Red Bull KTM (RC16) | +0.761s |
| 15 | Jack Miller | AUS | Ducati Lenovo (GP22) | +0.776s |
| 16 | Joan Mir | SPA | Suzuki Ecstar (GSX-RR) | +0.944s |
| 17 | Alex Marquez | SPA | LCR Honda (RC213V) | +0.970s |
| 18 | Franco Morbidelli | ITA | Monster Yamaha (YZR-M1) | +1.090s |
| 19 | Brad Binder | RSA | Red Bull KTM (RC16) | +1.107s |
| 20 | Michele Pirro | ITA | Aruba.it Racing (GP22) | +1.164s |
| 21 | Marc Marquez | SPA | Repsol Honda (RC213V) | +1.184s |
| 22 | Raul Fernandez | SPA | KTM Tech3 (RC16)* | +1.346s |
| 23 | Remy Gardner | AUS | KTM Tech3 (RC16)* | +1.546s |
| 24 | Darryn Binder | RSA | WithU Yamaha RNF (YZR-M1)* | +1.570s |
| 25 | Andre Dovizioso | ITA | WithU Yamaha RNF (YZR-M1) | +1.630s |
| 26 | Lorenzo Savadori | ITA | Aprilia Racing (RS-GP) | +1.653s |