Berikut update klasemen MotoGP 2021 setelah MotoGP Aragon 2021, Minggu (12/9/2021).
| POS. | PEMBALAP | NEGARA | TIM | POIN | SELISIH. |
| 1 | Fabio Quartararo | FRA | Monster Yamaha (YZR-M1) | 214 | |
| 2 | Francesco Bagnaia | ITA | Ducati Team (GP21) | 161 | (-53) |
| 3 | Joan Mir | SPA | Suzuki Ecstar (GSX-RR) | 157 | (-57) |
| 4 | Johann Zarco | FRA | Pramac Ducati (GP21) | 137 | (-77) |
| 5 | Jack Miller | AUS | Ducati Team (GP21) | 129 | (-85) |
| 6 | Brad Binder | RSA | Red Bull KTM (RC16) | 117 | (-97) |
| 7 | Aleix Espargaro | SPA | Aprilia Gresini (RS-GP) | 96 | (-118) |
| 8 | Maverick Viñales | SPA | Aprilia Gresini (RS-GP) | 95 | (-119) |
| 9 | Miguel Oliveira | POR | Red Bull KTM (RC16) | 87 | (-127) |
| 10 | Marc Marquez | SPA | Repsol Honda (RC213V) | 79 | (-135) |
| 11 | Jorge Martin | SPA | Pramac Ducati (GP21)* | 71 | (-143) |
| 12 | Alex Rins | SPA | Suzuki Ecstar (GSX-RR) | 68 | (-146) |
| 13 | Takaaki Nakagami | JPN | LCR Honda (RC213V) | 64 | (-150) |
| 14 | Pol Espargaro | SPA | Repsol Honda (RC213V) | 55 | (-159) |
| 15 | Alex Marquez | SPA | LCR Honda (RC213V) | 49 | (-165) |
| 16 | Enea Bastianini | ITA | Avintia Ducati (GP19)* | 45 | (-169) |
| 17 | Franco Morbidelli | ITA | Petronas Yamaha (YZR-M1) | 40 | (-174) |
| 18 | Iker Lecuona | SPA | KTM Tech3 (RC16) | 38 | (-176) |
| 19 | Danilo Petrucci | ITA | KTM Tech3 (RC16) | 37 | (-177) |
| 20 | Luca Marini | ITA | Sky VR46 Avintia Ducati (GP19)* | 28 | (-186) |
| 21 | Valentino Rossi | ITA | Petronas Yamaha (YZR-M1) | 28 | (-186) |
| 22 | Stefan Bradl | GER | HRC (RC213V) | 11 | (-203) |
| 23 | Dani Pedrosa | SPA | Red Bull KTM (RC16) | 6 | (-208) |
| 24 | Lorenzo Savadori | ITA | Aprilia Gresini (RS-GP)* | 4 | (-210) |
| 25 | Michele Pirro | ITA | Pramac Ducati (GP21) | 3 | (-211) |
| 26 | Tito Rabat | SPA | Pramac Ducati (GP21) | 1 | (-213) |
*pembalap rookie (debutan)